Name | 2'-DEOXY-CYTIDINE-5'-TRIPHOSPHATE LITHIUM SALT |
Synonyms | DCTP, LI DCTP LI-SALT 2'-deoxycytidine triphosphate Deoxycytidine triphosphate (dCTP) 2''-DEOXYCYTIDINE 5''-TRIPHOSPHATE (DCTP) 2'-DEOXY-CYTIDINE-5'-TRIPHOSPHATE LITHIUM SALT 2'-DEOXYCYTIDINE-5'-TRIPHOSPHORIC ACID, LITHIUM Cytidine 5'-(tetrahydrogen triphosphate), 2'-deoxy- [[[5-(4-amino-2-oxo-pyrimidin-1-yl)-3-hydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxyphosphonic acid |
CAS | 2056-98-6 |
EINECS | 218-153-9 |
Molecular Formula | C9H16N3O13P3 |
Molar Mass | 467.16 |
Density | 2.38±0.1 g/cm3(Predicted) |
Boling Point | 811.5±75.0 °C(Predicted) |
Appearance | Stabilized Aqueous Solution |
pKa | 0.80±0.50(Predicted) |
Storage Condition | Sealed in dry,Room Temperature |
In vitro study | Assays of thirteen cell lines, derived from mouse lymphomas, myelomas, myeloid tumors, and a mastocytoma, for sensitivity to growth inhibition by 1-β-D-arabinofuranosylcytosine (ara-C) revealed a spectrum between the most and least sensitive which differed 100-fold from each other. An inverse correlation between sensitivity and cellular Deoxycytidine triphosphate (2′-Deoxycytidine-5′-triphosphate, dCTP) content is found, and this suggested that sensitivity of cells might be increased if the dCTP content was lowered during cell exposure to ara-C. Deoxycytidine triphosphate trisodium salt is a phosphoethanolamine cytidylyltransferase substrate. |
Reference Show more | 1. Wang Di, Wei Lan, Liu Xi, et al. Effects of anti-metabolic antitumor drugs on nucleotide metabolism in human tumor cells [J]. Northwest Pharmaceutical Journal, 2015, 000(001):59-65. |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 2.114 ml | 10.569 ml | 21.138 ml |
5 mM | 0.423 ml | 2.114 ml | 4.228 ml |
10 mM | 0.211 ml | 1.057 ml | 2.114 ml |
5 mM | 0.042 ml | 0.211 ml | 0.423 ml |
biological activity | Deoxycytidine triphosphate (dCTP) is a nucleoside triphosphate that can be used for DNA synthesis. Deoxycytidine trihospose can be used for studies such as real-time PCR,cDNA synthesis and DNA sequencing. |